Current Epidemiology and Growing Resistance of Gram-Negative Pathogens

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Current Epidemiology and Growing Resistance of Gram-Negative Pathogens

In the 1980s, gram-negative pathogens appeared to have been beaten by oxyimino-cephalosporins, carbapenems, and fluoroquinolones. Yet these pathogens have fought back, aided by their membrane organization, which promotes the exclusion and efflux of antibiotics, and by a remarkable propensity to recruit, transfer, and modify the expression of resistance genes, including those for extended-spectr...

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Antimicrobial resistance among and therapeutic options against gram-negative pathogens.

Gram-negative bacterial pathogens are a common cause of infection, and the prevalence and rates of resistance among these pathogens to existing antimicrobial agents are increasing. beta-Lactamase-mediated resistance is of particular concern. High-level resistance attributable to beta-lactamase expression alone or in combination with other mechanisms is becoming increasingly prevalent among Ente...

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New Disturbing Trend in Antimicrobial Resistance of Gram-Negative Pathogens

1 Drug Resistance Proteomics Laboratory, Center for Antibiotic Resistance, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea, 2 Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Republic of Korea, 3 Structural Biology Laboratory, Marine Biotechnology Center, Korea Ocean Research and...

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Increased resistance of gram-negative urinary pathogens after kidney transplantation

BACKGROUND Urinary tract infection is the most common complication after kidney transplantation. It can cause severe sepsis and transplant loss. Emergence of drug resistance among gram-negative urinary pathogens is the current challenge for urinary tract infection treatment after kidney transplantation. METHODS This study analyzes the antimicrobial susceptibility of gram-negative urinary path...

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Fluoroquinolones Protective against Cephalosporin Resistance in Gram-negative Nosocomial Pathogens

In a matched case-control study, we studied the effect of prior receipt of fluoroquinolones on isolation of three third-generation cephalosporin-resistant gram-negative nosocomial pathogens. Two hundred eighty-two cases with a third-generation cephalosporin-resistant pathogen (203 with Enterobacter spp., 50 with Pseudomonas aeruginosa, and 29 with Klebsiella pneumoniae) were matched on length o...

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ژورنال

عنوان ژورنال: The Korean Journal of Internal Medicine

سال: 2012

ISSN: 1226-3303,2005-6648

DOI: 10.3904/kjim.2012.27.2.128